Structure of PDB 7jpl Chain A

Receptor sequence
>7jplA (length=1114) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
QNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGL
EKLEYFFLTVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFT
AILEQVNVVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALL
VLFMVIIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCARTGSGR
PCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVN
DAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSVFYWLV
ILIVALNTLSIASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGL
RQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLRCIRLLRLFKI
TKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRYDFE
DTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVC
IYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAVNATWFTNFILLFIL
LSSAALAAEDPIRAESVRNQILGYFDIAFTSVFTVEIVLKMTTYGYFNIL
DLLVVAVSLISMVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEECRGYYYVYKDGD
PTQMELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYRAIDSNEE
DMGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGDKNQRQC
VQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQ
HYHHISDILNVAFTIIFTLEMILKLLAFKARGYFGDPWNVFDFLIVIGSI
IDVILSEIDTFLSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPY
VALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRC
ATGEAWQEILLACSYGKLCDPESDYAPGEEYTCGTNFAYYYFISFYMLCA
FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKH
LDVTLLRRIQPPLG
3D structure
PDB7jpl Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca v 1.1 by Dihydropyridine Compounds*.
ChainA
Resolution3.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E292 E614 E1014 E240 E476 E735
BS02 C8U A V932 T935 S1011 M1057 V653 T656 S732 M778
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008331 high voltage-gated calcium channel activity
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006936 muscle contraction
GO:0045933 positive regulation of muscle contraction
GO:0051209 release of sequestered calcium ion into cytosol
GO:0055085 transmembrane transport
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0070588 calcium ion transmembrane transport
GO:0071313 cellular response to caffeine
GO:0098703 calcium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030315 T-tubule
GO:0034702 monoatomic ion channel complex
GO:1990454 L-type voltage-gated calcium channel complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7jpl, PDBe:7jpl, PDBj:7jpl
PDBsum7jpl
PubMed33125829
UniProtP07293|CAC1S_RABIT Voltage-dependent L-type calcium channel subunit alpha-1S (Gene Name=CACNA1S)

[Back to BioLiP]