Structure of PDB 7jn3 Chain A

Receptor sequence

>7jn3A (length=269) Species: 269446 (Rous sarcoma virus (strain Schmidt-Ruppin A))

PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI

3D structure

• PDB: 7jn3 Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
• Chain: A
• Resolution: 3.21 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	G49 V50 N51 P52 T143 T144 G145 I146 Q151 G152 A154 R158 L162 R201 R244 Y246	G49 V50 N51 P52 T143 T144 G145 I146 Q151 G152 A154 R158 L162 R201 R244 Y246
BS02	dna	A	E157 R161	E157 R161
BS03	ZN	A	H9 H13 C37	H9 H13 C37
BS04	ZZX	A	D64 S150 Q151 E157	D64 S150 Q151 E157
BS05	MG	A	D64 E157	D64 E157
BS06	MG	A	D64 D121	D64 D121

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:7jn3, PDBe:7jn3, PDBj:7jn3
• PDBsum: 7jn3
• PubMed: 33712691
• UniProt: P03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)