Structure of PDB 7jm7 Chain A

Receptor sequence

>7jm7A (length=683) Species: 9606 (Homo sapiens) [Search protein sequence]

SLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLV
ACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVG
SVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVS
AGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNF
VLSIYHGNLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN
ALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQG
GSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLF
TLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD
PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIV
GDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREK
VGVIVDVLSDTASNHNGFPVVEARLQGLILRSQLIVLLKHKVFVERRLRL
KDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVF
KLFRALGLRHLVVVDNRNQVVGLVTRKDLARYR

3D structure

PDB

7jm7 Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.

Chain

Resolution

2.82 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	A	E95 S96 S632 V635 T636 N657 H658 R767 L781 K785 D786	E5 S6 S539 V542 T543 N564 H565 R659 L673 K677 D678
BS02	CL	A	S204 V513	S114 V420
BS03	CL	A	G245 E247 G512 F514 I515	G155 E157 G419 F421 I422
BS04	0J1	A	V140 V222 R223 L224 L227 G260 I261 R265 S266 T267 S268 K285 R717	V50 V132 R133 L134 L137 G170 I171 R175 S176 T177 S178 K195 R609

Gene Ontology

	Molecular Function
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015108	chloride transmembrane transporter activity
GO:0015297	antiporter activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006821	chloride transport
GO:0030321	transepithelial chloride transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

	Cellular Component
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0034707	chloride channel complex
GO:0043231	intracellular membrane-bounded organelle

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7jm7, PDBe:7jm7, PDBj:7jm7
PDBsum	7jm7
PubMed	32749217
UniProt	P51798\|CLCN7_HUMAN H(+)/Cl(-) exchange transporter 7 (Gene Name=CLCN7)

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