Structure of PDB 7jlg Chain A

Receptor sequence
>7jlgA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
MNRKWEAKLKQIEEREEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECK
VGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKP
ANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHL
IFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHLFVD
LGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSS
LVSNVRFSDTLRILTCEP
3D structure
PDB7jlg Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H46 R47 Q48 G74 Q75 R76 Y78 R286 H26 R27 Q28 G54 Q55 R56 Y58 R206
BS02 DTP A R76 Y100 D114 E116 K165 S167 R288 N289 R291 K297 R56 Y80 D94 E96 K145 S147 R208 N209 R211 K217
BS03 CA A D114 E116 D94 E96
BS04 CA A D114 E116 D280 D94 E96 D200
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jlg, PDBe:7jlg, PDBj:7jlg
PDBsum7jlg
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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