Structure of PDB 7jl8 Chain A

Receptor sequence
>7jl8A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
MNRKWEAKLKQIEERASEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALE
CKVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFN
KPANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSR
HLIFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHLF
VDLGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFL
SSLVSNVRFSDTLRILTCEP
3D structure
PDB7jl8 Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H46 R47 Q48 G74 Q75 R76 Y78 T285 R286 R288 H28 R29 Q30 G56 Q57 R58 Y60 T207 R208 R210
BS02 dna A D280 R288 D202 R210
BS03 DTP A R76 Y100 D114 E116 K165 S167 H169 R288 N289 R291 K297 R58 Y82 D96 E98 K147 S149 H151 R210 N211 R213 K219
BS04 CA A D114 E116 D96 E98
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jl8, PDBe:7jl8, PDBj:7jl8
PDBsum7jl8
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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