Structure of PDB 7jl3 Chain A

Receptor sequence

>7jl3A (length=650) Species: 9606 (Homo sapiens)

SPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPKDEESRICKALFLY
TSHLRKYNDALIISEHARMKDALDYLKDFFSNVEIEQDLTQRFEEKLQEL
ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWI
EGNPKLSFLKPGILTGRGGMTLPAQKCILDAFKGDHNILIATSVADEGID
IAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINM
YKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKENKKLLCRK
CKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKKRAKIFCARQN
CSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPF

3D structure

• PDB: 7jl3 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
• Chain: A
• Resolution: 4.2 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K379 Q380 K750 C829 K888 K907	K141 Q142 K495 C567 K620 K639
BS02	rna	A	V514 K518 K635 R637 R664 T697 V699 K878 K880	V274 K278 K388 R390 R417 T442 V444 K610 K612
BS03	ADP	A	F241 R244 T266 G267 G269 K270 T271 D705 R732	F3 R6 T28 G29 G31 K32 T33 D450 R477
BS04	ALF	A	E373 G703 Q726 R730 R732	E135 G448 Q471 R475 R477
BS05	ZN	A	C810 C813 C864 C869	C548 C551 C596 C601

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:7jl3, PDBe:7jl3, PDBj:7jl3
• PDBsum: 7jl3
• PubMed: 33373584
• UniProt: O95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)