Structure of PDB 7jl0 Chain A

Receptor sequence

>7jl0A (length=662) Species: 9606 (Homo sapiens)

ELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKAS
EPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVV
KSCDIIISTAQILENSLLNLAGVQLSDFSLIIIDECHHTNKEAVYNNIMR
HYLMQKLKNNRLKKVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANL
DAFTIKTVKENLDQLKNQIQEPCKKFAIADREDPFKEKLLEIMTRIQTYC
QMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQIND
TIRMIDAYTHLETFYNEEKDKKFAVIEETDRFLMTLFFENNKMLKRLAEN
PEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEK
FAEVGVKAHHLIGAGSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEE
GLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIERE
TVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAK
HYNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVREKQ
INGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVE
LPITFPNLDYSE

3D structure

• PDB: 7jl0 Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
• Chain: A
• Resolution: 4.3 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K450 E451 M926 H927 W1003	K141 E142 M581 H582 W648
BS02	rna	A	V366 G392 T413 Q415 I416 R728 G756 H927	V62 G88 T109 Q111 I112 R385 G413 H582
BS03	ZN	A	C907 C910 C962 C964	C562 C565 C607 C609
BS04	ADP	A	R309 G334 K335 T336 R337 D797 K799 R824	R5 G30 K31 T32 R33 D453 K455 R480
BS05	ALF	A	K335 R822	K31 R478

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:7jl0, PDBe:7jl0, PDBj:7jl0
• PDBsum: 7jl0
• PubMed: 33373584
• UniProt: Q9BYX4|IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (Gene Name=IFIH1)