Structure of PDB 7jkz Chain A

Receptor sequence

>7jkzA (length=111) Species: 9606 (Homo sapiens) [Search protein sequence]

KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM
DMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQD
VFEMRFAKMPD

3D structure

PDB

7jkz Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.

Chain

Resolution

2.49 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YF6	A	W374 P375 P379 V380 D381 L385 L387 N433	W26 P27 P31 V32 D33 L37 L39 N85

External links

PDB	RCSB:7jkz, PDBe:7jkz, PDBj:7jkz
PDBsum	7jkz
PubMed	32453591
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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