Structure of PDB 7jky Chain A

Receptor sequence
>7jkyA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
LENPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB7jky Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
ChainA
Resolution1.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 YF6 A W81 P82 V87 D88 K91 L92 N140 D145 I146 M149 W40 P41 V46 D47 K50 L51 N99 D104 I105 M108
External links
PDB RCSB:7jky, PDBe:7jky, PDBj:7jky
PDBsum7jky
PubMed32453591
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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