Structure of PDB 7jkp Chain A

Receptor sequence
>7jkpA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
MNRKWEAKLKQIEEEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALECKV
GDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNKPA
NPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRHLI
FQLHDVAFKDNIHVGNFLRKILQPALDLLDLSFLVVKNNMGEKHLFVDLG
VYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLSSLV
SNVRFSDTLRILTCEP
3D structure
PDB7jkp Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
ChainA
Resolution2.592 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H46 R47 Q48 D73 G74 Q75 R76 Y78 R286 H25 R26 Q27 D52 G53 Q54 R55 Y57 R204
BS02 dna A D280 R288 D198 R206
BS03 DTP A R76 Y100 D114 E116 K165 S167 H169 R288 N289 R291 K297 R55 Y79 D93 E95 K144 S146 H148 R206 N207 R209 K215
BS04 CA A D114 E116 D93 E95
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jkp, PDBe:7jkp, PDBj:7jkp
PDBsum7jkp
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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