Structure of PDB 7jkl Chain A

Receptor sequence
>7jklA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
MNRKWEAKLKQIEERAEEPPSIWRLFHRQAQAFNFVKSCKEDVHVFALEC
KVGDGQRIYLVTTYAEFWFYYKSRKNLLHCYEVIPENAVCKLYFDLEFNK
PANPGADGKKMVALLIEYVCKALQELYGVNCSAEDVLNLDSSTDEKFSRH
LIFQLHDVAFKDNIHVGNFLRKILQPALDLLPDLSFLVVKNNMGEKHLFV
DLGVYTRNRNFRLYKSSKIGKRVALEVTEDNKFFPIQSKDVSDEYQYFLS
SLVSNVRFSDTLRILTCEP
3D structure
PDB7jkl Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
ChainA
Resolution2.384 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H46 R47 Q48 G74 Q75 R76 Y78 T285 R286 H27 R28 Q29 G55 Q56 R57 Y59 T206 R207
BS02 DTP A R76 Y100 E116 K165 S167 H169 R288 N289 R291 K297 R57 Y81 E97 K146 S148 H150 R209 N210 R212 K218
BS03 CA A D114 E116 D95 E97
Gene Ontology
Molecular Function
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0042276 error-prone translesion synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:7jkl, PDBe:7jkl, PDBj:7jkl
PDBsum7jkl
PubMed34188055
UniProtQ96LW4|PRIPO_HUMAN DNA-directed primase/polymerase protein (Gene Name=PRIMPOL)

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