Structure of PDB 7jhd Chain A

Receptor sequence
>7jhdA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWAK
RVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR
NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTDH
IHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEH
LYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB7jhd Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer.
ChainA
Resolution2.402 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 L372 V376 D538 E542 I46 L60 V64 D214 E218
BS02 V9J A A350 E353 L384 M388 L391 F404 M421 I424 H524 L525 A38 E41 L72 M76 L79 F92 M109 I112 H200 L201 BindingDB: EC50=0.800000nM
External links
PDB RCSB:7jhd, PDBe:7jhd, PDBj:7jhd
PDBsum7jhd
PubMed33177154
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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