Structure of PDB 7jga Chain A

Receptor sequence
>7jgaA (length=514) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
SAADIEGAIEDYVSSFSADTEREEIGTVIDAGDGIAHVEGLPSVMTQELL
EFPGGVLGVALNLDEHSVGAVILGEFEKIEEGQQVKRTGEVLSVPVGDAF
LGRVVNPLGQPIDGQGDIAAETRRALELQAPSVVQRQSVSEPLQTGIKAI
DAMTPIGRGQRQLIIGDRKTGKTAVCVDTILNQREAWLTGDPKQQVRCVY
VAIGQKGTTIASVKRALEEGGAMEYTTIVAAPASDAAGFKWLAPYTGSAI
GQHWMYNGKHVLIVFDDLSKQADAYRAISLLLRRPPGREAFPGDVFYLHS
RLLERCAKLSDELGGGSMTGLPIIETKANDISAFIPTNVISITDGQCFLE
SDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAF
AAFASDLDAASKAQLDRGARLVELLKQPQYSPLAVEEQVVAIFLGTQGHL
DSVPVEDVQRFESELLEHVKASHSDIFDGIRETKKLSEEAEEKLVSVINE
FKKGFQASDGSSVV
3D structure
PDB7jga Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K178 Q211 K212 R376
Catalytic site (residue number reindexed from 1) K172 Q205 K206 R370
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A K175 G177 K178 T179 A180 R365 Q433 Q435 K169 G171 K172 T173 A174 R359 Q427 Q429
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0032559 adenyl ribonucleotide binding
GO:0043531 ADP binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7jga, PDBe:7jga, PDBj:7jga
PDBsum7jga
PubMed33299175
UniProtA0R202|ATPA_MYCS2 ATP synthase subunit alpha (Gene Name=atpA)

[Back to BioLiP]