Structure of PDB 7h84 Chain A

Receptor sequence
>7h84A (length=163) Species: 37124 (Chikungunya virus) [Search protein sequence]
GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKN
SATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVT
RLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKE
WEKKISEAIQMRT
3D structure
PDB7h84 Group deposition for crystallographic fragment screening of Chikungunya virus nsP3 macrodomain
ChainA
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3TR A D31 V113 Y114 D34 V116 Y117
BS02 3TR A D10 I11 V33 R144 D13 I14 V36 R147
External links
PDB RCSB:7h84, PDBe:7h84, PDBj:7h84
PDBsum7h84
PubMed
UniProtQ8JUX6|POLN_CHIKS Polyprotein P1234

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