Structure of PDB 7gqu Chain A

Receptor sequence
>7gquA (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
FLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYG
KSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSEN
VLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEW
GHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQIT
CTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKM
TQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGM
GINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLN
RHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKAS
LGIMGTEKCCDNCRSRLDH
3D structure
PDB7gqu Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C908 C935 C936 C939 C382 C409 C410 C413
BS02 ADP A H546 S548 K550 Q553 T573 G574 G576 K577 S578 R857 H20 S22 K24 Q27 T47 G48 G50 K51 S52 R331
BS03 X1L A V570 A704 A706 C727 M845 E846 Y849 K898 H916 F917 V44 A178 A180 C201 M319 E320 Y323 K372 H390 F391
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:7gqu, PDBe:7gqu, PDBj:7gqu
PDBsum7gqu
PubMed38658751
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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