Structure of PDB 7gqt Chain A

Receptor sequence
>7gqtA (length=421) Species: 9606 (Homo sapiens) [Search protein sequence]
FLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYG
KSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSEN
VLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISER
DSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFD
RPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVT
GELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKA
DIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLT
EIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMG
TEKCCDNCRSRLDHGGRLEVL
3D structure
PDB7gqt Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C908 C935 C936 C939 C377 C404 C405 C408
BS02 ATP A H546 S548 Q553 G574 G576 K577 S578 R854 R857 H20 S22 Q27 G48 G50 K51 S52 R323 R326
BS03 ZN A H558 E563 H32 E37
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7gqt, PDBe:7gqt, PDBj:7gqt
PDBsum7gqt
PubMed38658751
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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