Structure of PDB 7gqs Chain A

Receptor sequence
>7gqsA (length=425) Species: 9606 (Homo sapiens) [Search protein sequence]
LWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGK
SLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENV
LTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWG
HDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITC
TGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMT
QQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMG
INKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNR
HLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASL
GIMGTEKCCDNCRSRLDHGGRLEVL
3D structure
PDB7gqs Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
ChainA
Resolution1.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A H546 S548 Q553 G574 G576 K577 S578 H19 S21 Q26 G47 G49 K50 S51
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:7gqs, PDBe:7gqs, PDBj:7gqs
PDBsum7gqs
PubMed38658751
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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