Structure of PDB 7fur Chain A

Receptor sequence
>7furA (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
ASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT
GSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENP
LSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLL
ISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVP
KHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLK
LMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLG
LCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYE
RNNEFPVFDE
3D structure
PDB7fur Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution1.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H229 C235 C236 C243
BS02 MG A E225 D227 E64 D66
BS03 MG A E225 D227 D319 E64 D66 D158
BS04 ATP A G212 S213 E225 D227 S380 E383 K414 S435 Y436 G51 S52 E64 D66 S219 E222 K253 S274 Y275
BS05 JUJ A T211 V228 M229 P306 D319 T321 R376 L377 S378 T50 V67 M68 P145 D158 T160 R215 L216 S217
External links
PDB RCSB:7fur, PDBe:7fur, PDBj:7fur
PDBsum7fur
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

[Back to BioLiP]