Structure of PDB 7fuq Chain A

Receptor sequence
>7fuqA (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFNPLSQFL
EGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRGSPAVTLLISEKISVD
ITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAEETWR
LSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKD
KKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLR
TEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB7fuq Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution1.757 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H214 C220 C221 C228
BS02 YUF A R376 S378 F379 S380 E383 Y436 T440 F443 Y483 F484 R200 S202 F203 S204 E207 Y260 T264 F267 Y307 F308
External links
PDB RCSB:7fuq, PDBe:7fuq, PDBj:7fuq
PDBsum7fuq
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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