Structure of PDB 7fuo Chain A

Receptor sequence
>7fuoA (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFPKENPLSQFL
EGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKSPAVTLLISEKISVD
ITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNQ
EETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLK
ERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYF
LQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB7fuo Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H219 C225 C226 C233
BS02 YUB A A247 R376 L377 F379 S380 E383 Y436 F443 N482 Y483 F484 I485 F488 A84 R205 L206 F208 S209 E212 Y265 F272 N311 Y312 F313 I314 F317
External links
PDB RCSB:7fuo, PDBe:7fuo, PDBj:7fuo
PDBsum7fuo
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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