Structure of PDB 7fun Chain A

Receptor sequence
>7funA (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFENPLSQFLEG
EILSASKMLSKFRKIIKEEINDIKDVIMKRKRGGSPAVTLLISEKISVDI
TLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAFQEETW
RLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFK
DKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCL
RTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB7fun Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H215 C221 C222 C229
BS02 YU6 A E216 D227 V228 M229 R376 F379 S380 E383 Y436 K439 T440 F443 Y483 F484 E53 D64 V65 M66 R201 F204 S205 E208 Y261 K264 T265 F268 Y308 F309
External links
PDB RCSB:7fun, PDBe:7fun, PDBj:7fun
PDBsum7fun
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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