Structure of PDB 7fum Chain A

Receptor sequence
>7fumA (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFENPLSQF
LEGEILSASKMLSKFRKIIKEEINDTDVIMKRKRGGSPAVTLLISEKISV
DITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAEETW
RLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFK
DKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCL
RTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
3D structure
PDB7fum Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H215 C221 C222 C229
BS02 YU6 A D227 V228 M229 R376 S378 F379 S380 E383 Y436 T440 F443 Y483 F484 D67 V68 M69 R201 S203 F204 S205 E208 Y261 T265 F268 Y308 F309
External links
PDB RCSB:7fum, PDBe:7fum, PDBj:7fum
PDBsum7fum
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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