Structure of PDB 7fue Chain A

Receptor sequence
>7fueA (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKEN
PLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTL
LISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQ
LKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVT
YFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVF
DE
3D structure
PDB7fue Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.169 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H221 C227 C228 C235
BS02 YQC A R376 L377 F379 S380 E383 Y436 T440 F443 N482 Y483 F484 I485 F488 L490 R207 L208 F210 S211 E214 Y267 T271 F274 N313 Y314 F315 I316 F319 L321
External links
PDB RCSB:7fue, PDBe:7fue, PDBj:7fue
PDBsum7fue
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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