Structure of PDB 7fuc Chain A

Receptor sequence
>7fucA (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLS
QFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRSPAVTLLISEKIS
VDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKGF
QEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTY
FLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
E
3D structure
PDB7fuc Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C404 H220 C234
BS02 YQL A R376 S378 F379 S380 E383 Y436 T440 F443 F484 R206 S208 F209 S210 E213 Y266 T270 F273 F314
External links
PDB RCSB:7fuc, PDBe:7fuc, PDBj:7fuc
PDBsum7fuc
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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