Structure of PDB 7fu4 Chain A

Receptor sequence
>7fu4A (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFNPLSQFL
EGEILSASKMLSKFRKIIKEEINDIDVIMKRKRGGSPAVTLLISEKISVD
ITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKQEET
WRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERF
KDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQC
LRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFD
3D structure
PDB7fu4 Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution1.926 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H216 C222 C223 C230
BS02 YMO A A247 R376 L377 F379 S380 F443 N482 F484 I485 F488 L490 A87 R202 L203 F205 S206 F269 N308 F310 I311 F314 L316
External links
PDB RCSB:7fu4, PDBe:7fu4, PDBj:7fu4
PDBsum7fu4
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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