Structure of PDB 7fu3 Chain A

Receptor sequence
>7fu3A (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKNPLSQFLE
GEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKIS
VDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKQE
ETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKE
RFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFL
QCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB7fu3 Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution1.822 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C396 C397 C404 H218 C224 C225 C232
BS02 YME A A247 R376 S378 Y436 N482 F488 L490 A85 R204 S206 Y264 N310 F316 L318
External links
PDB RCSB:7fu3, PDBe:7fu3, PDBj:7fu3
PDBsum7fu3
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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