Structure of PDB 7fu2 Chain A

Receptor sequence
>7fu2A (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKKENPLS
QFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMAVTLLISEKISVDIT
LALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHQEETWRLS
FSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKK
HLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTE
KLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB7fu2 Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C404 H212 C226
BS02 YM9 A R376 S378 F379 S380 I382 E383 Y436 T440 F443 Y483 F484 R198 S200 F201 S202 I204 E205 Y258 T262 F265 Y305 F306
External links
PDB RCSB:7fu2, PDBe:7fu2, PDBj:7fu2
PDBsum7fu2
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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