Structure of PDB 7fu1 Chain A

Receptor sequence
>7fu1A (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKEN
PLSQFLEGEILSASKMLSKFRKIIKEEINDDTDVIMKRKRGGSPAVTLLI
SEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPK
HAEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQ
LKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVT
YFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVF
D
3D structure
PDB7fu1 Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.074 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C397 C404 H221 C228 C235
BS02 YU2 A R376 L377 F379 S380 S434 Y436 F443 N482 R207 L208 F210 S211 S265 Y267 F274 N313
External links
PDB RCSB:7fu1, PDBe:7fu1, PDBj:7fu1
PDBsum7fu1
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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