Structure of PDB 7ftu Chain A

Receptor sequence

>7ftuA (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]

ASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT
GSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDDTDVIMKRKRGGSPAVTLLISEKI
SVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKE
GNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYL
LEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDN
CVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEF
PVFDE

3D structure

PDB

7ftu Crystal Structure of a human cyclic GMP-AMP synthase complex

Chain

Resolution

1.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	H390 C396 C397 C404	H224 C230 C231 C238
BS02	MG	A	E225 D227	E64 D66
BS03	MG	A	E225 D227 D319	E64 D66 D153
BS04	ATP	A	G212 S213 E225 D227 R376 S380 E383 K414 S435 Y436	G51 S52 E64 D66 R210 S214 E217 K248 S269 Y270
BS05	YPD	A	T211 D227 V228 R302 S305 P306 D319 T321 R376 S378 F433	T50 D66 V67 R136 S139 P140 D153 T155 R210 S212 F267

External links

PDB	RCSB:7ftu, PDBe:7ftu, PDBj:7ftu
PDBsum	7ftu
PubMed
UniProt	Q8N884\|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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