Structure of PDB 7ftr Chain A

Receptor sequence

>7ftrA (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]

ASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT
GSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENP
LSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLL
ISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVP
KHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLK
LMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLG
LCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYE
RNNEFPVFDE

3D structure

PDB

7ftr Crystal Structure of a human cyclic GMP-AMP synthase complex

Chain

Resolution

1.64 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	H390 C396 C397 C404	H229 C235 C236 C243
BS02	MG	A	E225 D227	E64 D66
BS03	MG	A	E225 D227 D319	E64 D66 D158
BS04	ATP	A	G212 S213 E225 D227 R376 S380 E383 K414 S435 Y436	G51 S52 E64 D66 R215 S219 E222 K253 S274 Y275
BS05	YQH	A	T211 D227 S305 P306 D319 T321 R376 S378 S380	T50 D66 S144 P145 D158 T160 R215 S217 S219

External links

PDB	RCSB:7ftr, PDBe:7ftr, PDBj:7ftr
PDBsum	7ftr
PubMed
UniProt	Q8N884\|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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