Structure of PDB 7ftp Chain A

Receptor sequence
>7ftpA (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]
ASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT
GSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENP
LSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKPAVTLLISEK
ISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHQE
ETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKE
RFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFL
QCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB7ftp Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C397 C404 H218 C225 C232
BS02 YQ8 A R376 K432 S434 Y436 H437 N482 F488 L490 R204 K260 S262 Y264 H265 N310 F316 L318
External links
PDB RCSB:7ftp, PDBe:7ftp, PDBj:7ftp
PDBsum7ftp
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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