Structure of PDB 7ftn Chain A

Receptor sequence
>7ftnA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVNGVVDHLLRRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKPKENPL
SQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLI
SEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPK
HAKQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLL
EQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNC
VTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFP
VFD
3D structure
PDB7ftn Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L174 R176 K198 H217 K407 L14 R16 K38 H57 K240
BS02 dna A S180 A183 N210 Y214 K384 S20 A23 N50 Y54 K217
BS03 ZN A H390 C396 C397 C404 H223 C229 C230 C237
External links
PDB RCSB:7ftn, PDBe:7ftn, PDBj:7ftn
PDBsum7ftn
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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