Structure of PDB 7ftm Chain A

Receptor sequence
>7ftmA (length=356) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKEN
PLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTL
LISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKY
LLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFD
NCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNE
FPVFDE
3D structure
PDB7ftm Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution1.698 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YO6 A R376 Y436 N482 F488 R211 Y271 N317 F323
BS02 YO6 A G161 A162 L165 G461 D465 E515 F516 G1 A2 L5 G296 D300 E350 F351
BS03 ZN A H390 C396 C397 C404 H225 C231 C232 C239
External links
PDB RCSB:7ftm, PDBe:7ftm, PDBj:7ftm
PDBsum7ftm
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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