Structure of PDB 7ftl Chain A

Receptor sequence
>7ftlA (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
ASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNT
GSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKKENPLSQ
FLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISE
KISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHA
KQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQ
LKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVT
YFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVF
D
3D structure
PDB7ftl Crystal Structure of a human cyclic GMP-AMP synthase complex
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H390 C397 C404 H221 C228 C235
BS02 YME A A247 R376 S378 S380 Y436 N482 F488 A86 R207 S209 S211 Y267 N313 F319
External links
PDB RCSB:7ftl, PDBe:7ftl, PDBj:7ftl
PDBsum7ftl
PubMed
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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