Structure of PDB 7fsf Chain A

Receptor sequence
>7fsfA (length=1102) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
AVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTL
KEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAP
TGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKI
FGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVF
VDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPG
ILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKL
VELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFK
VGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLELDKAPRF
VLARVLKEMGLIKAQENPDVEELRKIAKEHLTQKEFVEKVKEMFRGVVVK
DEDLELIIPDVYTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTR
LLLIAEEEIIEEAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPT
KAETLSRFLGRASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGI
HGVEEENGKFVPVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLR
ALREISLEADEILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITR
YGFKKARESVRFVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSA
GRVQSTVLGWIVEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVV
ELQEAEEEKNPLPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITF
HRTDSTRISLEGQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPID
ARELEEMIEEGLIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDV
DGKRMGIEQIVEILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPL
FTQASIVEEMKKRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVM
VYSYLKERYEKYVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLM
EE
3D structure
PDB7fsf Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
ChainA
Resolution2.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C621 C624 C635 C620 C623 C634
BS02 ZN A C11 C14 C29 C32 C10 C13 C28 C31
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008270 zinc ion binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0160097 reverse gyrase activity
Biological Process
GO:0006265 DNA topological change
GO:0006268 DNA unwinding involved in DNA replication
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fsf, PDBe:7fsf, PDBj:7fsf
PDBsum7fsf
PubMed37204816
UniProtO51934|RGYR_THEMA Reverse gyrase (Gene Name=rgy)

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