Structure of PDB 7fse Chain A

Receptor sequence
>7fseA (length=1040) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
AVNSKYHHSCINCGGLNTDERNERGLPCEVCLPEDSPSDIYRALLERKTL
KEYRFYHEFWNEYEDFRSFFKKKFGKDLTGYQRLWAKRIVQGKSFTMVAP
TGVGKTTFGMMTALWLARKGKKSALVFPTVTLVKQTLERLQKLADEKVKI
FGFYSSMKKEEKEKFEKSFEEDDYHILVFSTQFVSKNREKLSQKRFDFVF
VDDVDAVLKASRNIDTLLMMVGIPEEIIRKAFSTIKQGKIYERPKNLKPG
ILVVSSATAKPRGIRPLLFRDLLNFTVGRLVSVARNITHVRISSRSKEKL
VELLEIFRDGILIFAQTEEEGKELYEYLKRFKFNVGETWSEFEKNFEDFK
VGKINILIGVQAYYGKLTRGVDLPERIKYVIFWGTPSMRFSLEELIIPDV
YTYIQASGRSSRILNGVLVKGVSVIFEEDEEIFESLKTRLLLIAEEEIIE
EAEANWKELVHEVEESRRRSERELTDTSRSLLIIVESPTKAETLSRFLGR
ASSRKERNIIVHEAVTGEGVILFTATRGHVYDLVTKGGIHGVEEENGKFV
PVYNSLKRCRDCGYQFTEDRDECPVCSSKNIDDKTETLRALREISLEADE
ILVATDPDVEGEKISWDVTQYLLPSTRSLRRIEMHEITRYGFKKARESVR
FVDFNLVKAQIVRRVQDRWIGFELSGKLQKRFGRSNLSAGRVQSTVLGWI
VEREEEYKKSEKDFTLLVLENGVNLEVEGKIADDVVTVVELQEAEEEKNP
LPPYTTSSALSEISQKLRLGVQEVMDILQDLFEKGFITYHRTDSTRISLE
GQNVARTYLRKIGKEDIFMGRSWSTEGAHEAIRPVKPIDARELEEMIEEG
LIADLTKKHLRVYELIFNRFLASQSAAVKVKKQIVTVDVDGKRMGIEQIV
EILRDGWNLFVPLTVSPRFEHRTYKIKEKKFYKKHTVPLFTQASIVEEMK
KRGIGRPSTYAKIVEVLFRRGYVYEDKYKRVRPTRFGVMVYSYLKERYEK
YVTEETTRRLEEIMDKVERGEEDYQATLRLLYEEIKSLME
3D structure
PDB7fse Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C11 C14 C32 C10 C13 C31
BS02 ZN A C560 C563 C574 C577 C559 C562 C573 C576
BS03 ZN A E303 E306 E302 E305
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008270 zinc ion binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0160097 reverse gyrase activity
Biological Process
GO:0006265 DNA topological change
GO:0006268 DNA unwinding involved in DNA replication
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fse, PDBe:7fse, PDBj:7fse
PDBsum7fse
PubMed37204816
UniProtO51934|RGYR_THEMA Reverse gyrase (Gene Name=rgy)

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