Structure of PDB 7frv Chain A

Receptor sequence
>7frvA (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
AFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVER
LKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAI
ALDTKGPGSGGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALG
PEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLA
QKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCI
MLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPT
EVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQA
ARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLV
IVVTGWRPGSGYTNIMRVLSIS
3D structure
PDB7frv Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
ChainA
Resolution2.004 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP A L443 T444 T445 T446 S449 W494 R501 G526 R528 G530 G532 Y533 T534 L322 T323 T324 T325 S328 W373 R380 G405 R407 G409 G411 Y412 T413
BS02 OXL A K282 E284 A305 G307 D308 K161 E163 A184 G186 D187
BS03 MG A E284 D308 E163 D187
BS04 OD5 A F38 L39 Q405 F16 L17 Q284
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0030955 potassium ion binding
Biological Process
GO:0006096 glycolytic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7frv, PDBe:7frv, PDBj:7frv
PDBsum7frv
PubMed36753880
UniProtP30613|KPYR_HUMAN Pyruvate kinase PKLR (Gene Name=PKLR)

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