Structure of PDB 7fji Chain A

Receptor sequence
>7fjiA (length=1367) Species: 9606 (Homo sapiens) [Search protein sequence]
KEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLL
YGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVI
GILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRK
KNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIE
HNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPEAGKPSDLIL
TRLLVPPLCIRPSVNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDW
DFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR
VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQN
GPEVHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVV
LFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLP
QTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFD
RAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDD
NPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK
NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLL
KAKYELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIR
DHAGSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVP
DGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVD
TAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPA
AMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC
CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQ
VEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVAS
MNITLGVPRIKEIINASKAISTPIITAQLDKDDDADYARLVKGRIEKTLL
GEISEYIEEVFLPDDCFILVKLSLERIRLLRLEVNAETVRYSICTSKLRV
KPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRA
VIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI
EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAK
MKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLF
KLLHKADRDPNPPKRPL
3D structure
PDB7fji Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R1159 F1306 R1149 F1296
BS02 dna A S326 R353 R360 Q465 G869 S316 R343 R350 Q455 G859
BS03 ZN A C69 C79 C67 C77
BS04 ZN A C109 C112 C159 C107 C110 C157
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042797 tRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7fji, PDBe:7fji, PDBj:7fji
PDBsum7fji
PubMed34675218
UniProtO14802|RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (Gene Name=POLR3A)

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