Structure of PDB 7fha Chain A

Receptor sequence
>7fhaA (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
DIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFM
REKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGG
RRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQ
VLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLM
QDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLD
PKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPET
KKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNE
FDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLE
3D structure
PDB7fha Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2.
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADX A F408 Q409 L410 R411 N412 H418 L421 G511 R512 P514 A515 V552 A553 F186 Q187 L188 R189 N190 H196 L199 G289 R290 P292 A293 V330 A331
BS02 BGC A G445 G446 W447 T448 P454 L455 G223 G224 W225 T226 P232 L233
BS03 SO4 A R432 Y434 R210 Y212
Gene Ontology
Molecular Function
GO:0004781 sulfate adenylyltransferase (ATP) activity
Biological Process
GO:0000103 sulfate assimilation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7fha, PDBe:7fha, PDBj:7fha
PDBsum7fha
PubMed34818583
UniProtO95340|PAPS2_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (Gene Name=PAPSS2)

[Back to BioLiP]