Structure of PDB 7feh Chain A

Receptor sequence
>7fehA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVFPLNVRKGHPLLVAVK
ILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYME
NGDLNQFLSAHQLEDKPTISYPMLLHVAAQIASGMRYLATLNFVHRDLAT
RNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK
FTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVY
LSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNT
3D structure
PDB7feh Novel potent and highly selective DDR1 inhibitors from integrated lead finding
ChainA
Resolution1.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3UI A E672 M676 I685 T701 F762 H764 A783 D784 F785 E67 M71 I80 T96 F143 H145 A164 D165 F166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7feh, PDBe:7feh, PDBj:7feh
PDBsum7feh
PubMed
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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