Structure of PDB 7fee Chain A

Receptor sequence
>7feeA (length=486) Species: 9606,272844 [Search protein sequence]
QCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRS
LRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGV
TASFTAKVGSLFLAAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIV
IAVLPLLGWNCEKLQSVCSDIFPHIDKTYLMFWIGVVSVLLLFIVYAYMY
ILWKAHSHAGIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRF
DRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHG
NVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIAS
AVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDLSKFRENCKKR
AMSFSDQARMDIELAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKT
VFAFCSMLCLLNSTVDPIIYALRSKDLRHAFRSMFP
3D structure
PDB7fee Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A F208 A236 I243 F112 A140 I147
BS02 9GF A F170 S173 F174 F177 L193 T197 I267 F268 W356 M363 F379 S383 F74 S77 F78 F81 L97 T101 I171 F172 W429 M436 F452 S456
BS03 7IC A I169 F191 G195 S199 I245 A248 V249 I73 F95 G99 S103 I149 A152 V153
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004949 cannabinoid receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fee, PDBe:7fee, PDBj:7fee
PDBsum7fee
PubMed35637350
UniProtP21554|CNR1_HUMAN Cannabinoid receptor 1 (Gene Name=CNR1);
Q9V2J8

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