Structure of PDB 7fd0 Chain A

Receptor sequence
>7fd0A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
VIKMKSSDFLESAELDSGGFGKVSLAFHRTQGLMIMKTVYKGPNCIEHNE
ALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEM
STPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLG
LASFKMWSKLNLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY
ENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTF
PGIEEKFRPFYLSQLE
3D structure
PDB7fd0 Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3IU A S25 V31 I43 K45 M67 V76 L90 M92 D156 L157 S17 V23 I35 K37 M59 V68 L82 M84 D148 L149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7fd0, PDBe:7fd0, PDBj:7fd0
PDBsum7fd0
PubMed34851543
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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