Structure of PDB 7fcz Chain A

Receptor sequence
>7fczA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
IKMKSSDFLESAELDKVSLAFHRTQGLMIMKTVYKGNEALLEEAKMMNRL
RHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKASTPLSVKGRIILEI
IEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNGTL
YYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYQQLIMAIKSGNR
PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
3D structure
PDB7fcz Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3IF A K45 V76 L90 M92 D156 L157 L159 S161 F162 K31 V56 L70 M72 D134 L135 L137 S139 F140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7fcz, PDBe:7fcz, PDBj:7fcz
PDBsum7fcz
PubMed34851543
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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