Structure of PDB 7fcy Chain A

Receptor sequence
>7fcyA (length=190) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFD
LTVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDE
TLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAA
NARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPR
3D structure
PDB7fcy Crystal structure of M.tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
ChainA
Resolution1.848 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H73 E77 H152 H64 E68 H143
BS02 MN A H47 H176 E180 H38 H167 E171
BS03 47Z A H47 M107 H176 H177 E180 H38 M98 H167 H168 E171
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fcy, PDBe:7fcy, PDBj:7fcy
PDBsum7fcy
PubMed
UniProtP9WML9|HIS7_MYCTU Imidazoleglycerol-phosphate dehydratase (Gene Name=hisB)

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