Structure of PDB 7fc9 Chain A

Receptor sequence

>7fc9A (length=584) Species: 280699 (Cyanidioschyzon merolae strain 10D)

TTGVTARRIFALAWSSSATMIVIGFIASILEGATLPAFAIVFGRMFAVFT
KSKSQIEGETWKYSVGFVGIGVFEFIVAGSRTALFGIASERLARDLRVAA
FSNLVEQDVTYFDRRKAGELGGKLNNDVQVIQYSFSKLGAVLFNLAQCVV
GIIVAFIFAPALTGVLIALSPLVVLAGAAQMIEMSGNTKRSSEAYASAGS
VAAEVFSNIRTTKAFEAERYETQRYGSKLDPLYRLGRRRYISDGLFFGLS
MLVIFCVYALALWWGGQLIARGSLNLGNLLAAFFSAILGFMGVGQAAQVW
PDVTRGLGAGGELFAMIDRVPQYRRPDPGAEVVTQPLVLKQGIVFENVHF
RYPTRMNVEVLRGISLTIPNGKTVAIVGGSGAGKSTIIQLLMRFYDIEPQ
GGGLLLFDGTPAWNYDFHALRSQIGLVSQEPVLFSGTIRDNILYGKRDAT
DEEVIQALREANAYSFVMALPDGLDTEVGERGLALSGGQKQRIAIARAIL
KHPTLLCLDESTSALDAESEALVQEALDRMMASDGVTSVVIAHRLSTVAR
ADLILVMQDGVVVEQGNHSELMALGPSGFYYQLV

3D structure

• PDB: 7fc9 Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX.
• Chain: A
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	A	Y452 R455 S480 G483 K484 S485 T486 Q529 H643	Y352 R355 S380 G383 K384 S385 T386 Q429 H543
BS02	ZN	A	E610 H643	E510 H543
BS03	MG	A	S485 Q529	S385 Q429
BS04	ZN	A	D227 S292	D127 S192
BS05	MG	A	D227 T288 S292 E412	D127 T188 S192 E312
BS06	ZN	A	D551 E552	D451 E452
BS07	ZN	A	H449 E459	H349 E359
BS08	ZN	A	N447 H449	N347 H349
BS09	ZN	A	E219 E293	E119 E193
BS10	ZN	A	E131 E174	E31 E74

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7fc9, PDBe:7fc9, PDBj:7fc9
• PDBsum: 7fc9
• PubMed: 35059217
• UniProt: M1VAN7