Structure of PDB 7faq Chain A

Receptor sequence
>7faqA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
TRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ
NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQN
KLTDLEILALLIAALSHDLDHRGVNNSIMEHHHFDQCLMILNSPGNQILS
GLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQK
ELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGNKIPSMQVGFID
AICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQ
3D structure
PDB7faq Free energy perturbation (FEP)-guided scaffold hopping.
ChainA
Resolution2.20014 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H617 H653 D654 D764 H81 H117 D118 D212
BS02 2OI A Y612 I768 V782 F786 F787 M816 Q817 F820 Y76 I216 V230 F234 F235 M244 Q245 F248
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7faq, PDBe:7faq, PDBj:7faq
PDBsum7faq
PubMed35530128
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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