Structure of PDB 7fan Chain A

Receptor sequence
>7fanA (length=486) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
GAMVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQR
FFDDEIKKMGVENSYFPMFVSRHKLEKPEVAWVTHYGDSPLPEKIAIRPT
SETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQE
GHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKK
TTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSW
GCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKC
RELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKG
TARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKI
STFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIEAGMTGA
MKTLCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB7fan Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
ChainA
Resolution1.769 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1TI A R470 E472 K474 Q475 P476 L480 R481 T482 F485 Q555 A556 A557 G590 T592 R594 R131 E133 K135 Q136 P137 L141 R142 T143 F146 Q216 A217 A218 G251 T253 R255
BS02 PRO A T439 E441 W487 E489 H560 S588 W589 G590 T100 E102 W148 E150 H221 S249 W250 G251
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fan, PDBe:7fan, PDBj:7fan
PDBsum7fan
PubMed36854028
UniProtA0A125YZ49

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