Structure of PDB 7fam Chain A

Receptor sequence
>7famA (length=480) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFF
DDEIKKMGVENSYFPMFVSRHKLEPEVAWVTHYGDSPLPEKIAIRPTSET
IMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQEGHT
AHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTT
VEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSWGCT
TRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKCREL
KTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKGTAR
VVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKISTF
DEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIEAGAMKTLCI
PFDQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB7fam Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1XK A E472 K474 Q475 P476 L480 R481 T482 F485 W487 Q555 A557 T558 G590 T592 R594 E130 K132 Q133 P134 L138 R139 T140 F143 W145 Q213 A215 T216 G248 T250 R252
BS02 PRO A T439 E441 W487 E489 F534 H560 S588 W589 G590 T97 E99 W145 E147 F192 H218 S246 W247 G248
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fam, PDBe:7fam, PDBj:7fam
PDBsum7fam
PubMed36854028
UniProtA0A125YZ49

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