Structure of PDB 7fak Chain A

Receptor sequence
>7fakA (length=483) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFF
DDEIKKMGVENSYFPMFVSRHKLEKEKPEVAWVTHYGDSPLPEKIAIRPT
SETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQE
GHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKK
TTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTSW
GCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGKC
RELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAKG
TARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEKI
STFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIQAIEAGAMKT
LCIPFDQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB7fak Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
ChainA
Resolution1.899 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1UI A R470 E472 K474 Q475 P476 L480 R481 T482 F485 W487 Q555 A557 T592 R594 R131 E133 K135 Q136 P137 L141 R142 T143 F146 W148 Q216 A218 T253 R255
BS02 PRO A T439 E441 W487 E489 H491 F534 H560 W589 G590 T100 E102 W148 E150 H152 F195 H221 W250 G251
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7fak, PDBe:7fak, PDBj:7fak
PDBsum7fak
PubMed36854028
UniProtA0A7J6JUK2

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