Structure of PDB 7fac Chain A

Receptor sequence

>7facA (length=524) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence]

GFMGRIRSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHC
GTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIE
TRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASADIGSGHTGITGDNVE
TLNEDLLEILSRERVNINIVGDFHLNEEVAIILASFSASTSAFIDTIKSL
DYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQAAGVI
RSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNS
VIIMAYVTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKD
AWEILKFLITGVFDIVKGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVT
IAGAKLRSLNLGEVFIAQSKGLYRQCIRGKEQLQLLMPLKAPKEVTFLEG
DSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVGTPVCVNGLMLLEIK
DKEQYCALSPGLLATNNVFRLKGG

3D structure

PDB

7fac Crystal Structure of N-terminus of the non-structural protein 2 from SARS coronavirus

Chain

Resolution

2.71 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C32 C35 C50	C29 C32 C47
BS02	ZN	A	H91 Y96	H88 Y93

External links

PDB	RCSB:7fac, PDBe:7fac, PDBj:7fac
PDBsum	7fac
PubMed	35729072
UniProt	P0C6X7\|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

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